Home sweet home: How do virus specific T cells navigate to the skin?

In mucosal immunology, the importance of homing of specific T and B lymphocyte memory cells back to their antigen’s tissue of origin has long been established (1). Elucidation of the mechanisms of such homing and their role in pathogenesis and immunodeficiency may provide targets for immunotherapy or vaccines (2). Recently, there has been intense interest in lymphocyte homing during the pathogenesis of inflammatory skin diseases, particularly the role of memory T cells carrying the cutaneous lymphocyte-associated antigen (CLA) marker.